ea0015p107 | Cytokines and growth factors | SFEBES2008
Miquet Johanna G
, Gonzalez Lorena
, Zotta Elsa
, Bartke Andrzej
, Turyn Daniel
, Sotelo Ana I
Chronically elevated GH levels in GH-transgenic mice derive in accelerated growth and increased body weight. These animals present increased circulating IGF-I and hepatic IGF-I mRNA levels, as well as liver enlargement due to hypertrophy and hyperplasia, which frequently progress to hepatomas as the animals age.We have previously described that the GH-induced JAK2/STAT5 signalling pathway is desensitized in the liver of transgenic mice overexpressing GH....